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Palliative Prostate Artery Embolization for Prostate Cancer: A Case Series.

B Malling1, M A Røder2, M Lindh3

  • 1Department of Diagnostic Radiology, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. Brian.malling.01@regionh.dk.

Cardiovascular and Interventional Radiology
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PubMed
Summary
This summary is machine-generated.

Palliative prostate artery embolization (PAE) offers a safe and effective treatment for lower urinary tract symptoms (LUTS) in men with advanced prostate cancer (PCa), improving symptom scores and quality of life.

Keywords:
Clinical trialEmbolizationLower urinary tract symptomsPalliative careProstatic neoplasmsTherapeuticUrinary retention

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Area of Science:

  • Interventional Radiology
  • Urology
  • Oncology

Background:

  • Lower urinary tract symptoms (LUTS) and urinary retention are common in men with prostate cancer (PCa).
  • Prostate artery embolization (PAE) is an established treatment for benign prostatic hyperplasia-induced LUTS.
  • The efficacy of palliative PAE for LUTS in advanced PCa remains to be fully elucidated.

Purpose of the Study:

  • To evaluate the safety and efficacy of palliative PAE in managing LUTS or urinary retention in men with advanced prostate cancer (PCa).

Main Methods:

  • A prospective, single-center trial (ClinicalTrials.gov Identifier: NCT03104907) enrolled 15 men with advanced PCa experiencing LUTS or urinary retention.
  • Primary outcomes included ability to void without a catheter and International Prostate Symptom Score (IPSS) changes.
  • Paired t tests analyzed pre- and post-procedure data, with p < 0.05 considered significant.

Main Results:

  • Of 15 enrolled patients, 11 completed follow-up. Bilateral embolization was successful in 10 cases.
  • Urinary retention resolved in 1 of 6 patients, while LUTS improved in 5 patients, showing a mean IPSS reduction of 12.2 points.
  • Two Grade 1 and two Grade 3 complications (CIRSE classification) were reported.

Conclusions:

  • Palliative PAE demonstrates safety and efficacy in treating LUTS associated with advanced prostate cancer (PCa).
  • PAE offers a viable minimally invasive option for symptom management in this patient population.