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Palliative Prostate Artery Embolization for Prostate Cancer: A Case Series
B Malling1, M A Røder2, M Lindh3
1Department of Diagnostic Radiology, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. Brian.malling.01@regionh.dk.
Cardiovascular and Interventional Radiology
|May 8, 2019
Summary
Palliative prostate artery embolization (PAE) offers a safe and effective treatment for lower urinary tract symptoms (LUTS) in men with advanced prostate cancer (PCa), improving symptom scores and quality of life.
Area of Science:
- Interventional Radiology
- Urology
- Oncology
Background:
- Lower urinary tract symptoms (LUTS) and urinary retention are common in men with prostate cancer (PCa).
- Prostate artery embolization (PAE) is an established treatment for benign prostatic hyperplasia-induced LUTS.
- The efficacy of palliative PAE for LUTS in advanced PCa remains to be fully elucidated.
Purpose of the Study:
- To evaluate the safety and efficacy of palliative PAE in managing LUTS or urinary retention in men with advanced prostate cancer (PCa).
Main Methods:
- A prospective, single-center trial (ClinicalTrials.gov Identifier: NCT03104907) enrolled 15 men with advanced PCa experiencing LUTS or urinary retention.
- Primary outcomes included ability to void without a catheter and International Prostate Symptom Score (IPSS) changes.
- Paired t tests analyzed pre- and post-procedure data, with p < 0.05 considered significant.
Main Results:
- Of 15 enrolled patients, 11 completed follow-up. Bilateral embolization was successful in 10 cases.
- Urinary retention resolved in 1 of 6 patients, while LUTS improved in 5 patients, showing a mean IPSS reduction of 12.2 points.
- Two Grade 1 and two Grade 3 complications (CIRSE classification) were reported.
Conclusions:
- Palliative PAE demonstrates safety and efficacy in treating LUTS associated with advanced prostate cancer (PCa).
- PAE offers a viable minimally invasive option for symptom management in this patient population.
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