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Mild hyperbaric oxygen: mechanisms and effects.
1Laboratory of Cell Biology and Life Science, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto, 606-8501, Japan. ishihara.akihiko.8s@kyoto-u.ac.jp.
The Journal of Physiological Sciences : JPS
|May 8, 2019
Summary
Mild hyperbaric oxygen therapy, using specific pressure and oxygen levels, shows promise in improving metabolic health. This approach may help manage conditions like type 2 diabetes, hypertension, and Parkinson's disease.
Area of Science:
- Physiology
- Biomedical Science
Background:
- Metabolic syndrome and lifestyle-related diseases pose significant health challenges.
- Oxidative metabolism plays a crucial role in cellular and tissue health.
- Age-related decline in oxidative capacity and neurodegenerative diseases impact quality of life.
Purpose of the Study:
- To investigate the potential benefits of mild hyperbaric oxygen (mHBO) therapy on metabolic diseases.
- To evaluate the effects of mHBO on oxidative capacity in skeletal muscle.
- To assess the neuroprotective effects of mHBO in Parkinson's disease models.
Main Methods:
- Exposure of rats and mice to mild hyperbaric oxygen at 1266-1317 hPa with 35-40% oxygen.
- Assessment of metabolic syndrome and lifestyle-related diseases in rats.
- Evaluation of skeletal muscle oxidative capacity during growth and aging in rats and mice.
- Monitoring of dopaminergic neuron loss in mice with Parkinson's disease.
Main Results:
- Mild hyperbaric oxygen therapy inhibited and/or improved metabolic syndrome and lifestyle-related diseases in rats.
- mHBO accelerated growth-induced oxidative capacity in rat skeletal muscle and inhibited age-related decline in mice.
- The decrease in dopaminergic neurons in mice with Parkinson's disease was inhibited by mHBO.
Conclusions:
- Mild hyperbaric oxygen therapy offers a potential non-invasive strategy for improving oxidative metabolism.
- mHBO demonstrates therapeutic potential for metabolic diseases, including type 2 diabetes and hypertension.
- This therapy may also provide neuroprotection against neurodegenerative conditions like Parkinson's disease.
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