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Related Experiment Video

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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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White Matter Abnormalities in Major Depression Biotypes Identified by Diffusion Tensor Imaging.

Sugai Liang1,2, Qiang Wang1, Xiangzhen Kong3

  • 1Mental Health Centre, West China Hospital, Sichuan University, Chengdu, 610041, China.

Neuroscience Bulletin
|May 8, 2019
PubMed
Summary
This summary is machine-generated.

Major depressive disorder (MDD) shows three white-matter abnormality subtypes. Widespread disruptions correlate with greater neurocognitive deficits, aiding personalized treatment for MDD heterogeneity.

Keywords:
BiotypeDiffusion tensor imagingHeterogeneityHierarchal clusteringMajor depressive disorder

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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neurology

Background:

  • Major depressive disorder (MDD) diagnosis is complex due to heterogeneity.
  • Subtyping MDD using data-driven approaches, particularly white-matter abnormalities, is underexplored.
  • Understanding white-matter alterations may clarify MDD subtypes.

Purpose of the Study:

  • To identify distinct data-driven biotypes of MDD based on white-matter integrity.
  • To investigate the neurocognitive correlates of identified MDD subgroups.
  • To explore the potential for optimizing MDD treatment strategies through subtyping.

Main Methods:

  • Diffusion tensor imaging (DTI) was used to assess white-matter integrity in 116 MDD patients and 118 controls.
  • Hierarchical clustering and tract-based spatial statistics analyzed fractional anisotropy in 20 major fiber tracts.
  • Clinical and neurocognitive assessments compared identified subgroups with healthy controls.

Main Results:

  • Three white-matter abnormality subgroups were identified in MDD patients.
  • Subgroup 1 (25.9%) showed widespread white-matter disruption with sustained attention and memory deficits.
  • Subgroup 2 (43.1%) exhibited localized abnormalities (corpus callosum, cingulate) and delayed memory dysfunction.
  • Subgroup 3 (31.0%) had minimal, non-significant white-matter alterations and no significant cognitive deficits.

Conclusions:

  • MDD exhibits at least three distinct white-matter abnormality subtypes.
  • Severity of white-matter disruption correlates with the extent of neurocognitive impairment.
  • These findings support parsing MDD heterogeneity and developing type-specific treatments.