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Aberrant localization of signaling proteins in skin cancer: Implications for treatment

Thomas R Holmes1, Shravya Dindu1, Laura A Hansen1

  • 1Department of Biomedical Sciences, Creighton University, Omaha, Nebraska.

Molecular Carcinogenesis
|May 8, 2019
PubMed

Insights

Aberrant protein localization in cancer cells, particularly skin cancer, can drive tumor growth and resistance to therapy. Understanding these shifts offers new therapeutic targets for improved patient outcomes.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Medicine

Background:

  • Aberrant subcellular localization of signaling proteins confers cancer cell advantages like apoptosis resistance, invasiveness, and proliferation.
  • Nuclear to cytoplasmic shifts in tumor-promoting proteins correlate with poorer patient outcomes.
  • Dysregulated protein localization is a common hallmark of cancer, impacting key cellular processes.

Purpose of the Study:

  • To review the significance of dysregulated protein localization in cancer.
  • To focus on the role of altered protein localization in skin cancer.
  • To highlight the potential of targeting aberrant localization for cancer therapeutics.

Main Methods:

  • Literature review of studies on protein localization and cancer.
  • Analysis of signaling pathways affected by protein mislocalization.
  • Examination of therapeutic strategies targeting protein localization.

Main Results:

  • Altered localization of cell cycle and cell death regulators is frequent in cancer.
  • Aberrant localization can result in acquired prosurvival functions for cancer cells.
  • Specific protein localization shifts are critical in skin cancer progression.

Conclusions:

  • Dysregulated protein localization is a critical factor in cancer development and progression.
  • Targeting aberrant subcellular protein localization presents a promising therapeutic avenue.
  • Further research into protein localization mechanisms can yield novel anti-cancer drugs.
Keywords:
14-3-3CDC25cytoplasmic localizationexportinskin cancer

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