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Updated: Jun 15, 2026

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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Published on: February 3, 2022

Trifluoromethylated Proline Surrogates as Part of "Pro-Pro" Turn-Inducing Templates

Charlène Gadais1, Kevin Van Holsbeeck1,2, Samuel L C Moors3

  • 1Research Group of Organic Chemistry, Departments of Bioengineering Sciences and Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium.

Chembiochem : a European Journal of Chemical Biology
|May 8, 2019
PubMed
Summary

This study introduces novel trifluoromethylated proline analogues as enhanced beta-turn inducers in peptidomimetics. The (R)-Pro-(R)-TfmOxa template demonstrates superior conformational stability for designing peptide-based therapeutics.

Keywords:
NMR spectroscopybackbone constraintsbeta-turn inducersisomerizationpeptidomimetics

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