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Updated: Jan 25, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-Light-Driven, Photoredox-Catalyzed Cascade of ortho-Hydroxycinnamic Esters To Access 3-Fluoroalkylated
Dan Song1, Chao-Ming Wang1, Zhi-Peng Ye1
1College of Chemistry and Chemical Engineering , Central South University , Changsha 410083 , P. R. China.
Abstract:
A general and straightforward protocol for di-/perfluoroalkylation of ortho-hydroxycinnamic esters via a photoredox-catalyzed cascade was developed to access a variety of 3-fluoroalkylated coumarins. This method was characterized by all-in-one synthetic design, simplified operation, mild reaction conditions, and broad substrate scope. Moreover, a sequential one-pot procedure starting from commercially available salicylaldehyde was also successfully realized to synthesize 3-fluoroalkylated coumarins.
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