Assembly of Functionalized 4-Alkynylisoxazoles by Palladium-Catalyzed Three-Component Cascade
Jianxiao Li1, Ruikang Huang1, Can Li1
1Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, P. R. China.
Abstract:
A novel N-heterocyclic carbene (NHC)-palladium-catalyzed three-component cascade cyclization/alkynylation for the synthesis of structurally diverse 4-alkynylisoxazoles was efficiently developed in ionic liquids. The operational simplicity, without additives, no additional ligands, and 0.5 mol % catalyst loading under air are some of the attractive features of this present protocol.
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