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Thiol-disulphide homeostasis is an oxidative stress indicator in critically ill children with sepsis

Ganime Ayar1, Sanliay Sahin2, Yasemin Men Atmaca3

  • 1Universidad de Ciencias de la Salud, Hospital de Formación e Investigación en Salud Infantil y Enfermedades Pediátricas, Hematología y Oncología, Ankara, Turquía. ganimeayar@gmail.com.

Archivos Argentinos De Pediatria
|May 8, 2019
PubMed

Insights

This study reveals that thiol-disulphide homeostasis is altered in pediatric sepsis patients. Lower plasma thiol levels indicate a significant difference in children with sepsis in the Paediatric Intensive Care Unit.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Critical Care Medicine

Background:

  • Oxidative stress plays a critical role in the pathophysiology of sepsis.
  • Thiol-disulphide homeostasis is a novel marker of oxidative stress.
  • Understanding oxidative stress markers can improve sepsis prognosis in children.

Purpose of the Study:

  • To evaluate thiol-disulphide homeostasis as a novel oxidative stress marker in pediatric sepsis.
  • To determine the association between thiol-disulphide homeostasis and sepsis prognosis in children.
  • To compare oxidative stress markers between sepsis patients and healthy controls.

Main Methods:

  • Measured total thiol, native thiol, and disulphide levels in 38 pediatric sepsis patients and 40 healthy controls.
  • Assessed thiol/disulphide ratios and compared them between sepsis and control groups.
  • Correlated biochemical parameters with disease severity scores (PRISM, PLOS) and patient outcomes (survival).

Main Results:

  • Pediatric sepsis patients exhibited significantly lower plasma thiol levels compared to healthy controls (p < 0.001).
  • Abnormalities in thiol-disulphide homeostasis were observed in children with sepsis.
  • Thiol levels showed a significant difference between survivors and non-survivors (further analysis needed).

Conclusions:

  • Thiol-disulphide homeostasis is significantly altered in pediatric sepsis.
  • This novel oxidative stress marker may have prognostic implications in pediatric intensive care unit sepsis.
  • Further research is warranted to explore the therapeutic potential of targeting thiol-disulphide imbalance in sepsis.

Keywords:
ChildHomeostasisOxidative stressSepsisThiol-disulphide

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