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Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides
Keith Henry Moss1, Petya Popova2, Sine R Hadrup1
1DTU Health Technology , 202 Kemitorvet , 2800 Kongens Lyngby , Denmark.
Abstract:
Gene therapy is an exciting field that has the potential to address emerging scientific and therapeutic tasks. RNA-based gene therapy has made remarkable progress in recent decades. Nevertheless, efficient targeted delivery of RNA therapeutics is still a prerequisite for entering the clinics. In this review, we introduce current delivery methods for RNA gene therapeutics based on lipid nanoparticles (LNPs). We focus on the clinical appeal of recent RNA NPs and discuss existing challenges of fabrication and screening LNP candidates for effective translation into drugs of human metabolic diseases and cancer.
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