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Study of multidrug resistance in prevalent Gram-negative bacteria in burn patients in Iran: A systematic review and

Fatemeh Javanmardi1, Amir Emami1, Neda Pirbonyeh1

  • 1Burn and Wound Healing Research Center, Microbiology Department, Shiraz University of Medical Sciences, Shiraz, Iran.

Journal of Global Antimicrobial Resistance
|May 8, 2019
PubMed
Abstract

Insights

Multidrug-resistant Gram-negative bacteria (MDR-GNB) infections are highly prevalent in Iranian burn patients. This highlights the urgent need for improved infection control and antibiotic stewardship to combat rising antimicrobial resistance.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Multidrug-resistant Gram-negative bacteria (MDR-GNB) pose a significant threat, particularly in hospital settings.
  • Burn patients are especially vulnerable to infections due to compromised skin integrity.

Purpose of the Study:

  • To determine the prevalence of MDR-GNB infections among hospitalized burn patients in Iran.
  • To inform strategies for combating antimicrobial resistance in this vulnerable population.

Main Methods:

  • A comprehensive meta-analysis of existing literature was conducted.
  • Searches were performed across major scientific databases (PubMed, Scopus, Web of Science, EMBASE) and Iranian databases.
  • Statistical analysis utilized STATA13 with fixed- or random-effects models and Egger's test for publication bias.

Main Results:

  • The meta-analysis included 107 studies, analyzing data from 1292 initially identified articles.
  • Lowest resistance rates for Acinetobacter baumannii and Pseudomonas aeruginosa were to colistin (21% and 27%, respectively).
  • Highest resistance rates were observed for cefepime (98% for A. baumannii, 87% for P. aeruginosa).

Conclusions:

  • The prevalence of MDR-GNB infections in Iranian burn patients is alarmingly high.
  • Comprehensive infection control programs are essential.
  • Reducing antibiotic prophylaxis and increasing awareness of resistance patterns are critical.
Keywords:
Burn patientsDrug resistanceGram-negative bacteriaMeta-analysis

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