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Synergy between polymer crystallinity and nanoparticles size for payloads release.

Yupaporn Niyom1, Treethip Phakkeeree2, Adrian Flood1

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Polymer crystallinity significantly impacts drug release from nanoparticles. Controlling nanoparticle size and crystallinity allows for tunable drug delivery profiles, enhancing therapeutic efficacy.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology
  • Drug Delivery

Background:

  • Conventional drug delivery from polymer nanocarriers relies on bond cleavage or stimuli-responsive swelling/collapse.
  • The role of polymer crystallinity in drug release kinetics from nanoparticles remains underexplored.

Purpose of the Study:

  • To investigate the influence of polymer crystallinity on drug release profiles from polymer nanoparticles.
  • To establish crystallinity as a tunable parameter for controlling drug release kinetics.

Main Methods:

  • Polycaprolactone (PCL) nanoparticles were fabricated using the miniemulsion-solvent evaporation technique.
  • Nanoparticle crystallinity was modulated by varying polymer concentration, nanoparticle size, and blending with amorphous polymers (poly(vinyl formal), polystyrene).
  • Drug release profiles were analyzed in relation to nanoparticle size and crystallinity.

Main Results:

  • Nanoparticle crystallinity decreased significantly with decreasing nanoparticle diameter.
  • Drug release profiles demonstrated a clear dependence on the interplay between nanoparticle size and crystallinity.
  • Reduced crystallinity correlated with altered drug release rates.

Conclusions:

  • Polymer crystallinity is a critical factor influencing drug release from polymer nanoparticles.
  • The controlled modulation of crystallinity offers a novel strategy for tuning nanoparticle drug delivery systems.
  • This finding provides a new avenue for designing advanced nanocarriers with tailored release characteristics.