Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nuclear Overhauser Enhancement (NOE)01:06

Nuclear Overhauser Enhancement (NOE)

1.4K
Irradiation of a spin-active nucleus causes an increase or decrease in the signal intensity of neighboring nuclei that are not necessarily chemically bonded or involved in J-coupling. This phenomenon, called the nuclear Overhauser enhancement (NOE), results from through-space interactions between the nuclear spins. The NOE effect decreases with increasing internuclear distance and is generally not observed beyond 4 angstroms. In NOE, dipole-dipole interactions between neighboring spin-active...
1.4K
Nuclear Export of mRNA02:31

Nuclear Export of mRNA

8.7K
Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
8.7K
Genomics02:02

Genomics

39.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.9K
Non-nuclear Inheritance01:29

Non-nuclear Inheritance

23.1K
Most DNA resides in the nucleus of a cell. However, some organelles in the cell cytoplasm⁠—such as chloroplasts and mitochondria⁠—also have their own DNA. These organelles replicate their DNA independently of the nuclear DNA of the cell in which they reside. Non-nuclear inheritance describes the inheritance of genes from structures other than the nucleus.
23.1K
Nuclear Stability03:18

Nuclear Stability

23.0K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
23.0K
Nuclear Power02:36

Nuclear Power

9.4K
Controlled nuclear fission reactions are used to generate electricity. Any nuclear reactor that produces power via the fission of uranium or plutonium by bombardment with neutrons has six components: nuclear fuel consisting of fissionable material, a nuclear moderator, a neutron source, control rods, reactor coolant, and a shield and containment system.
Nuclear Fuels
Nuclear fuel consists of a fissile isotope, such as uranium-235, which must be present in sufficient quantity to provide a...
9.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developmentally programmed nuclear pore complex replacement enables oocyte specification.

bioRxiv : the preprint server for biology·2026
Same author

Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51.

Molecular cell·2025
Same author

Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51.

Molecular cell·2025
Same author

Editorial overview: Drivers, droplets, and deeds of nuclear genome organization.

Current opinion in genetics & development·2024
Same author

"Off-pore" nucleoporins relocalize heterochromatic breaks through phase separation.

bioRxiv : the preprint server for biology·2024
Same author

You are who your friends are-nuclear pore proteins as components of chromatin-binding complexes.

FEBS letters·2023

Related Experiment Video

Updated: Jan 25, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

411.7K

Nuclear pores in genome architecture and enhancer function.

Pau Pascual-Garcia1, Maya Capelson1

  • 1Department of Cell and Developmental Biology, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Current Opinion in Cell Biology
|May 8, 2019
PubMed
Summary

Nuclear pore complexes (NPCs) interact with enhancers and superenhancers, influencing genome architecture. This interaction may organize tissue-specific gene expression and chromatin organization.

More Related Videos

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells
11:25

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

Published on: January 25, 2020

10.9K
Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

35.6K

Related Experiment Videos

Last Updated: Jan 25, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

411.7K
3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells
11:25

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

Published on: January 25, 2020

10.9K
Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

35.6K

Area of Science:

  • Molecular Biology
  • Genomics
  • Cell Biology

Background:

  • Nuclear genome architecture is shaped by interactions with nuclear scaffolds.
  • Nuclear pore complexes (NPCs) are known for nuclear transport and chromatin interactions.
  • NPCs associate with enhancers and superenhancers, influencing genomic loops.

Purpose of the Study:

  • To review current models of enhancer function.
  • To discuss evidence of NPC-enhancer binding and its role in topological genome organization.
  • To explore how NPC targeting contributes to tissue-specific genome architecture and expression.

Main Methods:

  • Literature review of enhancer function models.
  • Analysis of recent evidence on NPC-enhancer interactions.
  • Examination of proposed models for NPC-mediated gene regulation.

Main Results:

  • NPCs bind to enhancers and superenhancers in metazoan genomes.
  • Specific NPC components facilitate the formation of genomic loops.
  • NPCs may promote phase separation of transcriptional compartments.

Conclusions:

  • NPCs play a role in topological genome organization by interacting with enhancers.
  • Targeting genes and enhancers to NPCs can influence tissue-specific genome architecture.
  • NPCs may contribute to gene expression programs through mechanisms like phase separation.