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Hormonal dynamics during luteal-follicular transition
The Journal of Clinical Endocrinology and Metabolism
|June 1, 1987
Summary
The luteal-follicular transition involves hormonal shifts, with follicle-stimulating hormone (FSH) increasing before and luteinizing hormone (LH) rising after menses onset. This selective FSH rise initiates folliculogenesis independently of GnRH.
Area of Science:
- Reproductive Endocrinology
- Neuroendocrinology
- Gynecology
Background:
- Understanding the neuroendocrine control of folliculogenesis is crucial for reproductive health.
- The luteal-follicular transition is a critical period for initiating the next ovarian cycle.
Purpose of the Study:
- To investigate the hormonal dynamics during the luteal-follicular transition.
- To elucidate the neuroendocrine basis for the initiation of folliculogenesis.
Main Methods:
- Collected blood samples at frequent intervals (2-h and 15-min) over multiple days from women.
- Analyzed serum levels of estradiol, progesterone, FSH, and LH.
Main Results:
- Luteolysis, marked by declining estradiol and progesterone, began at least 64 hours before menses.
- Follicle-stimulating hormone (FSH) levels selectively increased before and after menses onset.
- Luteinizing hormone (LH) levels rose significantly on the day of menses, with increased pulse frequency.
Conclusions:
- The initiation of folliculogenesis occurs during the late luteal phase via selective FSH augmentation.
- FSH secretion appears independent of hypothalamic Gonadotropin-releasing hormone (GnRH) pulsatility during this transition.
- Ovarian peptides may play a role in modulating FSH secretion during the luteal-follicular transition.