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Related Experiment Videos

Variable androgen receptor levels in infertile men.

A F Morrow, S Gyorki, G L Warne

    The Journal of Clinical Endocrinology and Metabolism
    |June 1, 1987
    PubMed
    Summary

    Androgen receptor (AR) levels were similar in infertile and normal men, but higher in those with chromosomal disorders. AR defects were found in 19% of infertile men, potentially indicating androgen resistance.

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    Long-term outcome of disorders of sex development.

    Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation·2008

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Genetics

    Background:

    • Androgen receptor (AR) is crucial for male reproductive function.
    • Dysregulation of AR signaling can contribute to male infertility.
    • Previous studies have yielded conflicting results on AR levels in infertile men.

    Purpose of the Study:

    • To determine androgen receptor (AR) levels in infertile men with primary seminiferous tubule disorders.
    • To investigate the relationship between AR levels and hormonal profiles (LH, FSH, testosterone) in infertile men.
    • To identify potential AR defects contributing to male infertility.

    Main Methods:

    • Labeled methyltrienelone used to quantify AR levels in cultured pubic skin fibroblasts.
    • Blood sampling at 10-min intervals for 6 hours to determine LH pulse patterns and mean serum LH levels.

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  • Comparison of AR levels and hormonal profiles between infertile men and normal controls.

    • Main Results:

    • Mean AR levels were similar between infertile and normal men.
    • Men with chromosomal disorders exhibited higher mean AR levels.
    • AR defects were identified in 14.2% of infertile men and 19.0% of men with idiopathic oligospermia.
    • Infertile men with low AR levels showed elevated mean LH levels and LH-testosterone product, suggesting androgen resistance.

    Conclusions:

    • AR levels are elevated in severe testicular failure associated with X-chromosome disorders.
    • AR defects are present in a significant proportion of infertile men with idiopathic oligospermia.
    • Elevated LH levels in men with seminiferous tubule disorders may indicate androgen resistance.