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Alcohol Consumption and Aortic Root Dilatation: Insights from the Corinthia Study
Evangelos Oikonomou1, George Lazaros1, Sotirios Tsalamandris1
11 First Cardiology Clinic, 'Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Angiology
|May 9, 2019
Summary
Daily alcohol consumption, particularly 3 or more drinks per day, is linked to a larger aortic root diameter. This finding highlights a potential risk factor for aortic dilatation and warrants further cardiovascular research.
Area of Science:
- Cardiovascular Medicine
- Aortic Diseases
- Epidemiology
Background:
- Aortic diameter and thoracic aortic aneurysm progression are influenced by various factors.
- Understanding modifiable risk factors like alcohol consumption is crucial for cardiovascular health.
- Previous research has not fully elucidated the specific impact of alcohol on aortic dimensions.
Purpose of the Study:
- To investigate the association between alcohol consumption patterns and aortic root and ascending aorta diameter.
- To determine if different levels of daily alcohol intake correlate with aortic dilatation.
- To assess the clinical implications of alcohol consumption on aortic dimensions.
Main Methods:
- Analysis of data from 1751 patients within the Corinthia study, utilizing echocardiography.
- Assessment of alcohol consumption via a detailed questionnaire on frequency, type, and quantity.
- Categorization of participants into everyday alcohol consumers (EDACs) and social drinkers (SoD), with further stratification of EDACs by daily intake (0-1, 1-2, ≥3 drinks/day).
Main Results:
- 40% of the study population were categorized as EDACs.
- EDACs exhibited increased aortic root diameter (AoRD) and elevated AoRD index compared to SoD.
- A dose-dependent, stepwise increase in aortic root and ascending aorta diameter was observed with increasing daily alcohol consumption, with ≥3 drinks/day associated with a 1.4 mm/m² increase in indexed aortic diameter.
Conclusions:
- Daily alcohol consumption is significantly associated with increased aortic root diameter.
- Higher levels of alcohol intake correlate with greater aortic dilatation.
- These findings suggest alcohol consumption as a potential risk factor for aortic root dilatation, with implications for clinical management and further research.
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