An image-based method to measure joint deformity in inflammatory arthritis: development and pilot study
Related Experiment Video
Updated: Jan 25, 2026

In Vivo Imaging Uncovers the Migratory Behavior of Leukocytes within the Joints
Published on: December 9, 2025
Travis F Henchie1, Ellen M Gravallese2, Todd L Bredbenner3
1a Department of Biomedical Engineering , Worcester Polytechnic Institute , Worcester , Massachusetts , USA.
Abstract:
Quantifying joint deformity in people with rheumatoid (RA) and psoriatic arthritis (PsA) remains challenging. Here, we demonstrate a new method to measure bone erosions and abnormal periosteal growths, based on the difference between a predicted healthy and actual diseased joint surface. We optimized the method by creating and measuring artificial bone erosions and growths. Then we measured 46 healthy and diseased patient surfaces. We found average sensitivity errors of ≤0.27 mm when measuring artificial erosions and growths. Patients had significantly more bone erosion than healthy subjects. Surface based outcomes are a novel way to interpret and quantify bone changes in PsA and RA.
More Related Videos
Related Concept Videos
Method of Joints
Since plane truss members are in the same plane, each joint is subjected to a coplanar and concurrent force system. To apply the method of joints, the first step is to...
Development of the Limb Synovial Joints
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Method of Joints: Problem Solving I
Method of Joints: Problem Solving II
Pilot and Numeric Relaying
Plastic Deformations

