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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
Noteworthy Literature Published in 2018 for Thoracic Organ Transplantation
Justin N Tawil1, Benjamin A Adams2, Alina Nicoara3
11 Medical College of Wisconsin, Milwaukee, WI, USA.
Insights
Reviewing 2018 publications for cardiothoracic transplant anesthesiologists, this summary highlights organ donor expansion strategies, post-transplant outcomes, extracorporeal support, and perioperative risk mitigation for improved patient care.
Area of Science:
- Anesthesiology
- Transplantation Medicine
- Cardiothoracic Surgery
Background:
- Review of key publications from 2018 relevant to cardiothoracic transplant anesthesiology.
- Focus on advancements in organ donor management and utilization.
Purpose of the Study:
- To summarize significant developments and research in cardiothoracic transplantation from 2018.
- To inform cardiothoracic transplant anesthesiologists about emerging strategies and outcomes.
Main Methods:
- Literature review of publications from 2018.
- Analysis of strategies for expanding donor organ availability.
- Examination of post-transplant outcomes and risk models.
- Assessment of extracorporeal support and allocation criteria.
Main Results:
- Highlighted strategies for increasing donor organ availability, including improved donor management, use of increased-risk donors, ex vivo perfusion, and donation after cardiac death.
- New data-driven risk models for assessing post-transplant outcomes beyond mortality.
- Prominent theme of extracorporeal support in cardiothoracic transplantation.
- Implementation of revised adult heart allocation criteria for objectivity and transparency.
- Identification of frailty and prehabilitation as key targets for perioperative risk mitigation.
Conclusions:
- Significant advancements in 2018 have expanded donor organ availability and refined post-transplant outcome assessment.
- Innovations in extracorporeal support and allocation criteria are transforming cardiothoracic transplantation.
- Focus on comprehensive perioperative risk mitigation, including frailty and prehabilitation, is crucial for improving patient outcomes.
Abstract:
Publications of note from 2018 are reviewed for the cardiothoracic transplant anesthesiologist. Strategies to expand the availability of donor organs were highlighted, including improved donor management, accumulating experience with increased-risk donors, ex vivo perfusion techniques, and donation after cardiac death. A number of reports examined posttransplant outcomes, including outcomes other than mortality, with new data-driven risk models. Use of extracorporeal support in cardiothoracic transplantation was a prominent theme. Major changes in adult heart allocation criteria were implemented, aiming to improve objectivity and transparency in the listing process. Frailty and prehabilitation emerged as targets of comprehensive perioperative risk mitigation programs.
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