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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
Published on: March 1, 2019
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Long noncoding RNAs in bladder cancer prognosis: A meta-analysis
Wei Zhu1, Hailang Liu1, Xinguang Wang1
1Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Pathology, Research and Practice
|May 9, 2019
Summary
High expression of long non-coding RNAs (lncRNAs) is linked to poorer survival and increased metastasis in bladder cancer (BC) patients. These lncRNAs may serve as novel predictive markers for clinical outcomes in BC.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long non-coding RNAs (lncRNAs) play a role in bladder cancer (BC) development.
- Understanding the clinical significance of lncRNAs in BC is crucial.
Purpose of the Study:
- To explore the association between specific lncRNAs and clinical outcomes in bladder cancer patients.
- To evaluate lncRNAs as potential prognostic biomarkers for BC.
Main Methods:
- Systematic literature search of PubMed, EMBASE, and Cochrane Library databases up to October 2018.
- Meta-analysis using fixed-effect or random-effect models to calculate pooled odds ratios (ORs) and hazard ratios (HRs).
Main Results:
- Upregulated lncRNAs significantly correlated with unfavorable overall survival (OS) (HR: 2.01) and recurrence-free survival (RFS) (HR: 2.05) in BC.
- High lncRNA expression was strongly associated with distant metastasis (DM) (OR: 8.16).
Conclusions:
- Abnormal expression of certain lncRNAs are promising novel markers for predicting clinical outcomes in bladder cancer.
- lncRNAs could aid in risk stratification and treatment decisions for BC patients.
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