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Engineering quorum quenching enzymes: progress and perspectives.

Shereen A Murugayah1,2, Monica L Gerth3,4

  • 1Department of Biochemistry, University of Otago, Dunedin, New Zealand.

Biochemical Society Transactions
|May 9, 2019
PubMed
Summary
This summary is machine-generated.

Quorum quenching enzymes are engineered to disrupt microbial pathogen communication (quorum sensing). This approach aims to control virulence by inactivating signalling molecules, though in vitro success needs translation to in vivo applications.

Keywords:
acyl-homoserine lactoneacylaselactonaseprotein engineeringquorum quenchingquorum sensing

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Area of Science:

  • Microbiology
  • Biochemistry
  • Protein Engineering

Background:

  • Quorum sensing is crucial for pathogen virulence in plants, animals, and humans.
  • Quorum quenching, disrupting microbial signalling, offers a novel strategy for pathogen control.

Purpose of the Study:

  • To review enzyme engineering efforts for quorum quenching.
  • To explore tailoring enzyme stability, specificity, and activity for acyl-homoserine lactone inactivation.

Main Methods:

  • Focus on protein engineering approaches for enzyme modification.
  • Examples of engineered enzymes targeting acyl-homoserine lactone signalling molecules.

Main Results:

  • Protein engineering can enhance stability, specificity, and activity of quorum quenching enzymes.
  • Demonstrated success in tailoring enzyme properties through various engineering strategies.

Conclusions:

  • Enzyme engineering is a viable strategy for developing quorum quenching therapeutics.
  • Bridging the gap between in vitro biochemical findings and in vivo applications remains a key challenge.