Related Experiment Video

Updated: Jan 25, 2026

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation
07:53

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation

Published on: January 9, 2019

33.8K

MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms

Valentina Gifford1, Yoshifumi Itoh2

  • 1The Kennedy Institute of Rheumatology, University of Oxford, Oxford, U.K.

Biochemical Society Transactions
|May 9, 2019
PubMed

Insights

Membrane-type 1 matrix metalloproteinase (MT1-MMP) enhances cell migration and invasion by modifying the cellular environment. This review explores how MT1-MMP

Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a key enzyme in the matrix metalloproteinase (MMP) family.
  • MT1-MMP plays a crucial role in modifying the cellular microenvironment.
  • It is implicated in cell migration and invasion across various cell types and conditions.

Purpose of the Study:

  • To review the multifaceted roles of MT1-MMP in promoting cell motility.
  • To elucidate the proteolytic and non-proteolytic mechanisms underlying MT1-MMP-dependent cell migration.
  • To provide a comprehensive understanding of MT1-MMP as a cell motility enhancer.

Main Methods:

  • Literature review of studies on MT1-MMP function.
  • Analysis of research detailing MT1-MMP's interactions with the extracellular matrix and cell adhesion molecules.
  • Examination of studies investigating MT1-MMP's impact on cellular metabolism.

Main Results:

  • MT1-MMP degrades the extracellular matrix, creating pathways for cell migration.
  • It enhances cell motility by shedding adhesion molecules and altering cell metabolism.
  • MT1-MMP acts as a multifunctional enhancer of cell movement.

Conclusions:

  • MT1-MMP is a critical regulator of cell migration and invasion through both enzymatic and non-enzymatic functions.
  • Understanding MT1-MMP's mechanisms is vital for addressing physiological and pathological processes.
  • MT1-MMP represents a significant target for therapeutic strategies aimed at controlling cell motility.
Keywords:
ECMMT1-MMPcell migrationcollageninvasion

More Related Videos

A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl05:20

A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl

Published on: November 28, 2014

13.8K
Proteolytically Degraded Alginate Hydrogels and Hydrophobic Microbioreactors for Porcine Oocyte Encapsulation07:45

Proteolytically Degraded Alginate Hydrogels and Hydrophobic Microbioreactors for Porcine Oocyte Encapsulation

Published on: July 30, 2020

5.9K

Related Concept Videos

Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.5K
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.7K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.2K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
4.5K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
3.2K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.4K