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Updated: Jan 25, 2026
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
An Optimal Capillary Screen Cut-off of Thyroid Stimulating Hormone for Diagnosing Congenital Hypothyroidism: Data
Prashant Verma1, Seema Kapoor2, Mani Kalaivani3
1Department of Pediatrics, Lok Nayak Hospital and Maulana Azad Medical College, New Delhi, India.
Objective:
To determine an appropriate cut-off of capillary Thyroid stimulating hormone (TSH) for congenital hypothyroidism.
Study Design:
Cross-sectional.
Participants:
174,000 neonates born in different hospitals of Delhi, India, from November 2014 to October 2016.
Main Outcome Measures:
Correlation between initial and repeat capillary TSH level and subsequent venous free thyroxine (fT4) level.
Results:
102 newborns with initial/ repeat capillary TSH level of ≥20 mIU/L (n=174) were confirmed to have congenital hypothyroidism at mean (SD) age of 5 (4) days. A good correlation between capillary TSH level and confirmatory venous fT4 level and postnatal age of sampling was obtained (r -0.6, -0.4). The area under the ROC curve (AUC) was 0.81 (95%CI 0.75 to 0.88), indicating referral capillary TSH level of 20 mIU/L to be a good predictor of subsequent high venous TSH level.
Conclusions:
A cut off of ≥20 mIU/L for capillary TSH screening beyond 24 hours of life is optimal in the Indian setting for deciding further recall and workup, keeping a balance between sensitivity and recall rate.
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