Related Experiment Video

Updated: Jan 25, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.5K

Profile of Pediatric Scrub Typhus in Odisha, India

Madhusmita Bal1, Mahesh Prasad Mohanta2, Suneeta Sahu3

  • 1ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha, India.

Indian Pediatrics
|May 9, 2019
PubMed

Insights

Scrub typhus is a significant cause of acute febrile illness in children in Odisha, with nearly half of cases confirmed. Early antibiotic treatment with doxycycline or azithromycin proved effective in managing this infection.

Area of Science:

  • Pediatric Infectious Diseases
  • Epidemiology
  • Tropical Medicine

Background:

  • Acute febrile illness in children presents a diagnostic challenge in endemic areas.
  • Scrub typhus, a bacterial infection transmitted by mites, is often underdiagnosed.
  • Odisha, India, experiences seasonal outbreaks of febrile illnesses.

Purpose of the Study:

  • To determine the prevalence and clinical characteristics of scrub typhus in children with acute febrile illness in Odisha.
  • To assess the diagnostic utility of serological and molecular methods for scrub typhus.
  • To evaluate the treatment response to antibiotics.

Main Methods:

  • A prospective study was conducted on children (<15 years) with fever (>5 days) in four agro-climatic zones of Odisha.
  • Patients were screened for common febrile illnesses including scrub typhus, malaria, leptospirosis, dengue, and typhoid.
  • Scrub typhus diagnosis was confirmed using IgM ELISA and PCR, with clinical data and treatment outcomes recorded.

Main Results:

  • Out of 413 children evaluated, 48.7% tested positive for scrub typhus.
  • Systemic complications occurred in 5.5% of scrub typhus cases, and eschars were observed in 17.9%.
  • A five-day course of Doxycycline and/or Azithromycin demonstrated clinical effectiveness in treating scrub typhus.

Conclusions:

  • Scrub typhus is a major contributor to childhood morbidity during the monsoon season in Odisha.
  • The findings underscore the importance of considering scrub typhus in the differential diagnosis of febrile illnesses in this region.
  • Prompt diagnosis and appropriate antibiotic therapy are crucial for favorable outcomes in pediatric scrub typhus.
Abstract

More Related Videos

Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry03:37

Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry

Published on: June 6, 2025

410
Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

475

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
214
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
276
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
200
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.1K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
261
Taping Over Different Ground Profiles01:12

Taping Over Different Ground Profiles

Taping over varying ground profiles requires careful adaptation to achieve accurate measurements. On smooth, level ground with minimal vegetation, the tape can rest directly on the ground. Here, the taping team, typically consisting of a head and a rear tapeman, coordinates their positions with clear communication. The rear tapeman holds the tape at the starting point and guides the head tapeman toward a range pole placed beyond the endpoint, using hand or voice signals to ensure alignment.On...
358