Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

Rheumatic Heart Disease I: Introduction

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

Rheumatic Heart Disease IV: Nursing Management

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...

Rheumatic Heart Disease III: Medical Management

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CD38 defines a therapeutically targetable pathogenic T cell population for precision immunotherapy in autoimmune diabetes.

bioRxiv : the preprint server for biology·2026

Same author

Microbial and immune determinants of disease severity and death in pediatric pneumonia.

medRxiv : the preprint server for health sciences·2026

Same author

Real-world clinical evaluation of the Inflammatix TriVerity test for sepsis at the emergency department: an Acutelines study.

Internal and emergency medicine·2026

Same author

Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection.

Scientific reports·2026

Same author

Human vaccine responses regulated by parallel cytokine pathways.

Nature immunology·2026

Same author

Serum proteomic atlas reveals distinct molecular signatures of lupus nephritis activity, chronicity, and treatment response.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: Jan 25, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

Single-cell technologies - studying rheumatic diseases one cell at a time.

Peggie Cheung^1,2, Purvesh Khatri^1,3, Paul J Utz^4,5

¹Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.

Nature Reviews. Rheumatology

|May 9, 2019

Summary

Single-cell multi-omics analysis reveals insights into rheumatic diseases. Understanding individual immune cell roles in pathogenesis can identify new therapeutic targets and biomarkers for complex autoimmune conditions.

More Related Videos

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations

Published on: September 17, 2012

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

Related Experiment Videos

Last Updated: Jan 25, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations

Published on: September 17, 2012

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

Area of Science:

Immunology
Rheumatology
Genomics

Background:

Immune cell coordination is vital for pathogen defense and host tolerance.
Dysregulated immune responses in rheumatic diseases involve specific cell subsets.
Understanding these cells is key to unraveling complex disease etiology.

Purpose of the Study:

To explore the role of individual immune cells in rheumatic disease pathogenesis.
To leverage single-cell technologies for identifying disease mechanisms.
To discover novel therapeutic targets and biomarkers in rheumatic diseases.

Main Methods:

High-dimensional single-cell dissection across multiple omics levels (transcriptomic, proteomic, epigenomic).
Multi-omics integrative analyses using advanced experimental platforms.
Application of single-cell technologies in rheumatology research.

Main Results:

Technological advances enable detailed analysis of cellular heterogeneity.
Identification of dysregulated molecular mechanisms in rheumatic disease patients is facilitated.
Potential for discovering new therapeutic targets and biomarkers.

Conclusions:

Single-cell multi-omics approaches are transforming immunology and have significant potential in rheumatology.
These technologies offer a powerful lens to study the pathogenesis of rheumatic diseases.
A deeper understanding of molecular pathways driving rheumatic diseases is anticipated.