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A rare case of sorafenib-induced severe hyponatremia

Misbahuddin Khaja1, Frantz Torchon2, Konstantin Millerman2

  • 1Division of Pulmonary/Critical Care Medicine, Bronx Care Health System, Icahn School of Medicine at Mount Sinai, Bronx, NY, USA.

SAGE Open Medical Case Reports
|May 9, 2019
PubMed
Abstract

Insights

Sorafenib, used for liver cancer, can rarely cause severe low sodium levels (hyponatremia). Stopping the drug improved the patient's condition, highlighting the need for early detection of this adverse effect.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Sorafenib is a tyrosine kinase inhibitor for advanced renal cell and hepatocellular carcinoma.
  • Common sorafenib side effects include rash, diarrhea, nausea, and hand-foot syndrome.

Observation:

  • A 90-year-old male with hepatocellular cancer developed weakness one week after starting sorafenib.
  • The patient presented with hyponatremia, a known electrolyte imbalance in cancer patients.

Findings:

  • The patient's hyponatremia resolved after discontinuing sorafenib.
  • This suggests a rare instance of sorafenib-induced hyponatremia.

Implications:

  • Sorafenib, while effective for hepatocellular cancer, carries a risk of serious complications like hyponatremia.
  • Prompt identification and management of sorafenib-induced hyponatremia are crucial to prevent adverse outcomes.
Keywords:
Sorafenibhepatocellular cancerhyponatremiaweakness

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