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Periodontal condition in growing subjects with Marfan Syndrome: a case-control study

Nicolò Venza1, Carlotta Danesi1, Diego Contò1

  • 1Department of Clinical Sciences and Translational Medicine, University of Roma "Tor Vergata", Roma, Italia.

Peerj
|May 9, 2019
PubMed
Abstract

Insights

Patients with Marfan syndrome (MFS) exhibit significantly higher plaque levels and generalized oral inflammation compared to healthy individuals. This study highlights the importance of monitoring oral health in growing MFS patients.

Area of Science:

  • Genetics and Molecular Biology
  • Periodontology
  • Pediatric Dentistry

Background:

  • Marfan syndrome (MFS) is a genetic connective tissue disorder caused by fibrillin-1 mutations.
  • Orofacial features can aid in MFS identification.
  • While severe periodontitis is noted in MFS, detailed data on Italian pediatric populations is lacking.

Purpose of the Study:

  • To investigate the periodontal status of growing subjects with Marfan syndrome.
  • To compare oral health parameters in MFS patients versus a control group.

Main Methods:

  • 16 MFS patients (Marfan Group) and 20 controls (Control Group) were assessed.
  • Periodontal parameters included Marginal Gingival Thickness (GT), Plaque Index (PI), Bleeding On Probing (BOP), and Modified Periodontal Screening and Recording (PSR).

Main Results:

  • The Marfan Group showed a significantly higher Plaque Index (59% vs. 21%) and Bleeding On Probing (36% vs. 16%) compared to the Control Group.
  • A statistically significant difference in Modified Periodontal Screening and Recording index distribution was observed across all sextants between the groups.

Conclusions:

  • Marfan syndrome patients present with increased plaque accumulation and generalized oral inflammation.
  • These findings underscore the need for vigilant oral health management in pediatric MFS cases.
Keywords:
Gingival conditionGrowing subjectsMarfan SyndromePeriodontal condition

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