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Published on: August 26, 2013
Can follicular Emmprin and BMP 4 levels predict ICSI outcome?
Ozguc Takmaz1, Dilara Yozgatli2, Selin Ozaltin3
1Department of Obstetrics and Gynecology, Acibadem Mehmet Ali Aydinlar University, Buyukdere Cd. No:40, Maslak, 34457, Sariyer/İstanbul, Turkey. ozguctakmaz@hotmail.com.
Purpose:
To evaluate the relationship of clinical pregnancy rates with bone morphogenetic proteins 2-4-7 (BMP 2, 4, 7), growth differentiation factor 9 (GDF 9), and Emmprin levels in follicular fluid of intracytoplasmic sperm injection patients.
Methods:
Follicular fluid of 77 patients who underwent ICSI procedure was collected during the oocyte retrieval procedure. And follicular fluid levels of BMP 2, BMP 4, BMP 7, GDF 9, and Emmprin (Basigin) were measured and compared for clinical pregnancy rates.
Results:
Follicular levels of BMP 4 was significantly higher whereas Emmprin levels were lower in patients who had achieved clinically diagnosed pregnancy compared with those who did not achieve clinical pregnancy after ICSI procedure (P = 0.007 and P = 0.035, respectively). BMP 2, BMP 7, and GDF 9 levels were comparable for both groups.
Conclusion:
Clinical pregnancy rates after ICSI may be associated with follicular fluid levels of Emmprin and BMP 4. Follicular levels of Emmprin and BMP 4 can be used as a marker (as markers for predicting ICSI outcomes) for a better ICSI outcome.
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