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The pericyte microenvironment during vascular development.

Laura B Payne1, Huaning Zhao1,2, Carissa C James1,3

  • 1Center for Heart and Reparative Medicine, Fralin Biomedical Research Institute, Roanoke, Virginia.

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Summary
This summary is machine-generated.

Vascular pericytes are crucial for blood vessel development and stability. This review highlights their roles in microcirculation, from early development to disease, emphasizing their interaction with endothelial cells.

Keywords:
endothelial cellspericytesvascular morphogenesis

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Area of Science:

  • Cell Biology
  • Vascular Biology
  • Developmental Biology

Background:

  • Vascular pericytes are essential for microcirculation integrity and homeostasis.
  • Pericytes support endothelial cell junctions and deposit extracellular matrix (ECM).
  • Pericyte dysfunction is implicated in diseases like cancer and diabetic retinopathy.

Purpose of the Study:

  • To review the multifaceted roles of vascular pericytes in microcirculation development and remodeling.
  • To focus on the local microenvironment's influence on pericyte function.
  • To examine pericyte involvement in pathological conditions.

Main Methods:

  • Literature review of pericyte contributions to vascular development.
  • Analysis of pericyte-endothelial cell interactions during angiogenesis.
  • Discussion of pericyte roles in vessel maturation and quiescence.

Main Results:

  • Pericytes are involved from the earliest stages of vascular development, guided by specific recruitment cues.
  • Pericyte-endothelial cell crosstalk, including signaling and ECM deposition, is vital for angiogenic sprouting.
  • Pericytes mediate the transition from active remodeling to stable, quiescent vasculature.

Conclusions:

  • Vascular pericytes are key regulators of microcirculation development, stability, and disease.
  • Understanding pericyte-endothelial cell interactions is critical for therapeutic strategies.
  • Pericyte functions extend across vascular development, remodeling, and maturation phases.