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Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
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Four-Coordinate Copper Halonitrosyl {CuNO}10 Complexes
Jamey K Bower1, Alexander Yu Sokolov1, Shiyu Zhang1
1Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave, Columbus, OH, USA.
Angewandte Chemie (International Ed. in English)
|May 9, 2019
Summary
Researchers synthesized stable copper nitrosyl complexes, [Cl3CuNO]- and [Br3CuNO]-, which can release and recapture nitric oxide (NO). These complexes show reactivity with biological nucleophiles, offering insights into copper-nitrosyl chemistry.
Area of Science:
- Inorganic Chemistry
- Bioinorganic Chemistry
- Coordination Chemistry
Background:
- Copper nitrosyl complexes are biologically relevant but difficult to isolate.
- Understanding their structure and reactivity is crucial for biological applications.
Purpose of the Study:
- To synthesize and characterize stable copper nitrosyl complexes.
- To investigate their electronic structure and reactivity.
Main Methods:
- Synthesis of [Cl3CuNO]- and [Br3CuNO]- complexes.
- Characterization using X-ray diffraction and spectroscopy.
- Computational analysis using CASSCF/NEVPT2 methods.
Main Results:
- Stable copper(II)-nitrosyl radical (CuII-NO.) complexes were synthesized.
- These complexes exhibit reversible nitric oxide (NO) release and recapture.
- Demonstrated nitrosative reactivity with biological nucleophiles like amines, alcohols, and thiols.
Conclusions:
- The study provides isolable examples of copper nitrosyl complexes with a CuII-NO. ground state.
- These complexes offer a platform for studying NO-related biological processes.
- Their reversible NO handling and reactivity suggest potential applications in medicinal chemistry.
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