Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review

Area of Science:

• Pharmacology
• Oncology
• Natural Products

Background:

• Cancer incidence and mortality rates remain high despite advancements in treatment.
• Chinese herbal medicines demonstrate significant antitumor potential.
• Amygdalin, found in bitter almonds, exhibits antitumor, antioxidant, anti-inflammatory, and immunoregulatory activities.

Purpose of the Study:

• To review the structural characteristics and antitumor mechanisms of amygdalin.
• To summarize recent research on amygdalin's progress and achievements.
• To explore the potential clinical value of amygdalin in cancer therapy.

Main Methods:

• Literature review of pharmacological studies on amygdalin.
• Analysis of amygdalin's effects on cell cycle, apoptosis, and immune function.
• Examination of research on amygdalin's efficacy in solid tumors like lung, bladder, and renal cell carcinoma.

Main Results:

• Amygdalin demonstrates antitumor effects in solid tumors.
• Mechanisms include affecting cell cycle, inducing apoptosis and cytotoxicity, and regulating immune function.
• Amygdalin possesses antioxidant, antibacterial, anti-inflammatory, and immunoregulatory properties.

Conclusions:

• Amygdalin shows potential for treating solid tumors.
• Further research is required to determine optimal dosage and combination therapies.
• Investigating artificial synthesis may enhance amygdalin's therapeutic benefits and reduce adverse effects.