Related Experiment Video
Updated: Jan 25, 2026

Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Acute myocardial infarction complicating ischemic stroke: is there room for cangrelor?
Nuccia Morici1,2, Stefano Nava3, Alice Sacco1
1Unità di Cure Intensive Cardiologiche, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Insights
Managing acute myocardial infarction (AMI) with ischemic stroke requires careful consideration of antithrombotic therapy. Cangrelor infusion offers a safe and effective treatment option, preventing both ischemic and hemorrhagic complications.
Area of Science:
- Cardiology
- Neurology
- Pharmacology
Background:
- Acute myocardial infarction (AMI) occurring concurrently with ischemic stroke presents a significant clinical challenge.
- Fear of bleeding complications often leads to conservative management, potentially increasing mortality.
- Percutaneous coronary intervention (PCI) in these cases is linked to reduced in-hospital mortality.
Abstract:
Acute myocardial infarction (AMI) complicating ischemic stroke is a well known and undertreated event. A conservative management is not infrequent in these settings, due to the fear of hemorrhagic complications related to antithrombotic therapy. Notably, an invasive approach with a primary percutaneous coronary intervention (PCI) has been shown to be associated with a lower in-hospital mortality in patients with concomitant ischemic stroke and AMI. The optimal antiplatelet regimen in these cases has been not clearly defined, yet. We report two cases of patients with AMI complicating ischemic stroke, successfully treated with cangrelor infusion, which was started during PCI and maintained up to 48 h at bridge therapy dosage (0.75 mcg/kg/min). Both patients underwent successful PCI in the acute phase, and neither ischemic nor hemorrhagic complications occurred during in-hospital stay.
Related Concept Videos
Hemodialysis II: Procedure and Complications
Diabetes: Symptoms, Diagnosis, and Complications
Pneumonia III: Complications and Assessment
Asthma-III: Symptoms and Complications
Classification of Asthma
Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

