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Updated: Jan 25, 2026
06:36
A Novel Tenorrhaphy Suture Technique with Tissue Engineered Collagen Graft to Repair Large Tendon Defects
Published on: December 10, 2021
3.3K
Light-Activated Tissue-Integrating Sutures as Surgical Nanodevices
Deepanjan Ghosh1, Russell Urie2, Andy Chang2
1Biological Design, Arizona State University, Tempe, AZ, 85287, USA.
Advanced Healthcare Materials
|May 9, 2019
Summary
Laser-activated tissue-integrating sutures (LATIS) offer improved soft tissue repair by combining collagen fibers with gold nanorods. This innovation enhances healing and reduces complications compared to traditional sutures.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Surgical Innovation
Background:
- Conventional sutures are primary for soft tissue repair but lack immediate sealing, risking infection and leakage.
- Non-absorbable sutures and staples can cause tissue trauma, worsened by removal.
- Cyanoacrylate glues have limited use due to brittleness and toxicity.
Purpose of the Study:
- To introduce novel nanodevices, laser-activated tissue-integrating sutures (LATIS), for enhanced soft tissue approximation and repair.
- To evaluate the efficacy of LATIS in a preclinical model, focusing on biomechanical recovery and tissue healing.
Main Methods:
- Development of LATIS fibers by incorporating gold nanorods into collagen.
- Utilizing near-infrared laser light for photothermal activation of LATIS.
- Assessing skin closure efficacy and biomechanical recovery in a mouse model.
Main Results:
- LATIS fibers exhibited robust photothermal responses upon laser irradiation.
- LATIS demonstrated superior biomechanical recovery of incised skin compared to conventional sutures.
- Histopathology revealed improved epidermal gap repair, indicating accelerated tissue recovery.
Conclusions:
- LATIS synergizes conventional suturing with laser-activated tissue integration for faster sealing and repair.
- This technology presents a novel approach for improved soft tissue healing and reduced surgical complications.
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