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Updated: Jan 25, 2026
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Fabrication of Tongue Extracellular Matrix and Reconstitution of Tongue Squamous Cell Carcinoma In Vitro
Published on: June 20, 2018
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KRAS mutations in tongue squamous cell carcinoma
Yusuke Akagi1, Tomoyasu Tachibana2, Yorihisa Orita3
1a Department of Otolaryngology , National Hospital Organization Okayama Medical Center , Okayama , Japan.
Acta Oto-Laryngologica
|May 9, 2019
Summary
KRAS mutations in tongue cancer (TC) are not linked to p16 expression and may indicate a poor prognosis. Further research into KRAS mutations beyond codons 12 and 13 is needed for TC.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Genetics
Background:
- p16INK4a (p16) expression in tongue cancer (TC) lacks association with human papillomavirus (HPV).
- KRAS mutations, frequently found in codon 12, have been sparsely investigated in relation to p16 status in TC.
Purpose of the Study:
- To investigate the impact of KRAS mutations on tongue cancer.
- To explore the relationship between KRAS mutations and p16 expression in TC.
Main Methods:
- Analysis of clinical records and surgical specimens from 85 TC patients.
- Detection of KRAS mutations in codons 12 and 13 using tumor sample analysis.
- Assessment of p16 staining for moderate to strong nuclear and cytoplasmic expression.
Main Results:
- p16 staining was positive in 11.8% of cases.
- A KRAS mutation was identified in 1.2% of cases, with negative p16 staining.
- The patient with a KRAS mutation experienced lung metastasis and mortality within 43 months, despite early-stage diagnosis.
Conclusions:
- KRAS mutations in TC are independent of p16 expression.
- KRAS mutations may serve as a predictive marker for poor prognosis in tongue cancer.
- Further investigation into KRAS mutations outside codons 12 and 13 is warranted to clarify their prognostic significance in TC.
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