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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

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Mortality risk factors in patients with advanced heart failure and diabetes mellitus

Łukasz Siedlecki1, Bożena Szyguła-Jurkiewicz1, Wioletta Szczurek2

  • 13rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland

Kardiologia Polska
|May 9, 2019
PubMed

Insights

Prognosis in advanced heart failure (HF) and diabetes mellitus (DM) is poor. Permanent atrial fibrillation, red blood cell distribution width (RDW), and platelet-to-lymphocyte ratio (PLR) independently predict mortality in these patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Hematology

Background:

  • Advanced heart failure (HF) and diabetes mellitus (DM) significantly worsen patient prognosis and treatment outcomes.
  • Accurate prognostic assessment is crucial for managing patients with both advanced HF and DM.

Purpose of the Study:

  • To identify prognostic factors influencing survival in patients with advanced HF and concomitant DM.

Main Methods:

  • Retrospective analysis of clinical and laboratory data from 367 patients with advanced HF (NYHA class III-IV) and DM.
  • Exclusion of patients with hematological disorders, steroid treatment, or incomplete data.
  • Endpoint: All-cause mortality over a mean follow-up of 4.4 years.

Main Results:

  • Overall mortality rate was 53.7% during follow-up.
  • Independent predictors of death identified via multivariate analysis include permanent atrial fibrillation (HR 1.57), red blood cell distribution width (RDW) (HR 1.05), and platelet-to-lymphocyte ratio (PLR) (HR 1.004).

Conclusions:

  • Permanent atrial fibrillation, RDW, and PLR are significant independent risk factors for long-term mortality in advanced HF patients with DM.
  • These hematological parameters offer valuable prognostic information in this high-risk population.
Abstract

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