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Updated: Jan 25, 2026

Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
Applicability of papain solutions in immunohematology
Laís Priscila De Santis1, Patrícia Carvalho Garcia1, Valéria Nogueira Dias Paes Secco1
1Universidade Estadual Paulista "Júlio de Mesquita Filho", Botucatu, SP, Brazil.
Objective:
To compare the enzyme activity of different presentations of papain solution to validate in-house preparations.
Methods:
Two papain solutions were prepared, and the third presentation was a commercial solution. Tests were carried out with samples of red cells typed as weak RhD.
Results:
In-house prepared papain solutions showed similar enzyme reactivity, and statistically no differences compared to the enzyme activity of the commercial solution.
Conclusion:
Evaluating the cost-benefit ratio, the in-house prepared papain solutions present more economic advantages, and can be incorporated into immunohematological routines as a way to cope with periods of financial crisis and cost-containment policies.
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