How to define chronic pruritus: Symptom or disease?
1Department of Dermatology, Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
Experimental Dermatology
|May 9, 2019
Summary
Chronic pruritus (CP), defined as itching for 6+ weeks, often persists independently of underlying diseases due to neuronal sensitization. This suggests CP may require its own management strategies beyond treating the initial cause.
Area of Science:
- Dermatology
- Neurology
- Clinical Medicine
Background:
- Chronic pruritus (CP) is a prevalent, burdensome symptom in many diseases, typically expected to resolve with the underlying condition.
- Clinical observations indicate CP frequently persists independently of the primary disease course, necessitating distinct management approaches.
Purpose of the Study:
- To explore the concept of chronic pruritus as a distinct entity, separate from its originating disease.
- To discuss the potential role of neuronal sensitization in the chronification of pruritus.
- To encourage dialogue and provide guidance on managing chronic pruritus.
Main Methods:
- Literature review and clinical experience synthesis.
- Discussion of pruritus pathophysiology, focusing on neuronal sensitization.
- Comparative analysis of CP's role across various pruritogenic diseases.
Main Results:
- Chronic pruritus may become disconnected from its initial cause due to neuronal sensitization, establishing its own disease course.
- Pruritus can be viewed not only as a symptom but also as an independent condition.
- Current understanding necessitates further research into CP's mechanisms and independent management.
Conclusions:
- Chronic pruritus (CP) can evolve into a condition requiring its own management, independent of the underlying disease.
- Neuronal sensitization is a key factor in CP's persistence and independent course.
- Further research is crucial for a comprehensive understanding and improved treatment of chronic pruritus.
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