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Nigrosome 1 imaging: technical considerations and clinical applications
Eung Yeop Kim1, Young Hee Sung2, Jongho Lee3
11Department of Radiology, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea.
The British Journal of Radiology
|May 9, 2019
Summary
Nigrosome 1, a key brain region affected in Parkinson's disease, can be visualized using specialized MRI techniques. This review clarifies its anatomical definition and imaging methods for better diagnosis of parkinsonism.
Area of Science:
- Neuroimaging
- Neuropathology
- Radiology
Background:
- Nigrosome 1, a substantia nigra region, is severely affected in idiopathic Parkinson's disease.
- MRI susceptibility-weighted imaging has identified nigrosome 1 in the dorsal substantia nigra.
- Standardization of imaging methods is needed for widespread clinical use.
Purpose of the Study:
- To revisit the anatomical definition of nigrosome 1 using high-spatial-resolution MRI.
- To guide readers in identifying nigrosome 1 abnormalities.
- To discuss current 3 Tesla imaging status and improvements for nigrosome 1 assessment.
Main Methods:
- Review of anatomical definitions and MRI techniques.
- Focus on high-spatial-resolution susceptibility map-weighted MRI.
- Illustration of imaging findings in patients with parkinsonism.
Main Results:
- Clarification of nigrosome 1's anatomical location and imaging characteristics.
- Demonstration of improved imaging quality for better assessment.
- Practical examples of nigrosome 1 imaging in parkinsonism.
Conclusions:
- High-resolution susceptibility map-weighted MRI aids in defining nigrosome 1.
- Standardized imaging protocols are crucial for clinical application.
- Further research into nigrosome 1 imaging holds potential for Parkinson's disease diagnosis.
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