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Domain-specific mechanical modulation of VWF-ADAMTS13 interaction

Zhenhai Li1,2, Jiangguo Lin1,3, Todd Sulchek1,4

  • 1Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332.

Molecular Biology of the Cell
|May 9, 2019
PubMed
Summary

Mechanical forces regulate how Von Willebrand factor (VWF) interacts with ADAMTS13. This study used single-molecule force spectroscopy to reveal distinct binding sites and calcium dependencies, uncovering complex interactions crucial for circulation.

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