Related Experiment Video
Updated: Jan 25, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Structural progression in axial spondyloarthritis.
Krystel Aouad1, Nelly Ziade1, Xenofon Baraliakos2
1Rheumatology department, Saint-Joseph University, Beirut, Lebanon; Hotel-Dieu de France Hospital, Alfred Naccache boulevard, Achrafieh, PO BOX 166830, Beirut, Lebanon.
Early diagnosis and effective treatments are crucial for managing axial spondyloarthritis (axSpA) and preventing functional disability. This review explores predictors of structural progression and the impact of treatments like biologics on axSpA.
Area of Science:
- Rheumatology
- Immunology
- Radiology
Background:
- Functional disability in axial spondyloarthritis (axSpA) stems from structural progression, posing a significant management challenge.
- Early diagnosis is key for better disease control and management of axSpA.
- Understanding axSpA's natural history and predictive factors for structural progression has improved.
Purpose of the Study:
- To review predictors of radiographic progression in axSpA patients.
- To summarize current evidence on the effect of treatments on structural progression in axSpA.
Main Methods:
- Literature review of imaging studies and long-term follow-up data.
- Analysis of evidence on non-steroidal anti-inflammatory drugs (NSAIDs), TNF inhibitors, and IL-17 inhibitors.
- Evaluation of emerging therapies for halting disease progression.
Main Results:
- NSAIDs' impact on structural progression remains conflicting.
- Biologic DMARDs, including TNF inhibitors and IL-17 inhibitors, show promise in retarding radiographic damage.
- Novel drugs demonstrate potential in halting axSpA progression.
Conclusions:
- Identifying predictors of structural progression is vital for axSpA management.
- Biologic therapies offer significant potential in mitigating structural damage in axSpA.
- Ongoing research into novel treatments is essential for improving long-term outcomes in axSpA.
More Related Videos
12:59Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation
Published on: February 28, 2021
05:56Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
Published on: April 3, 2016
Related Concept Videos
Axial and Appendicular Muscles
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and...
General Case of Eccentric Axial Loading
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical...
Overview of the Axial Skeleton
The axial skeleton of the...
Normal Strain under Axial Loading
Fimbriae, Pili, and Axial Filaments
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...