Related Experiment Video
Updated: Jan 25, 2026

08:29
In vivo Measurement of Knee Extensor Muscle Function in Mice
Published on: March 4, 2021
5.6K
Simultaneous Bilateral Extensor Mechanism Disruptions: More Than Double the Trouble?
Christina Seifert1, Jordan Vokes1, Aaron Roberts1
1Department of Orthopaedics, University of Rochester, Rochester, New York.
The Journal of Knee Surgery
|May 9, 2019
Summary
Simultaneous bilateral extensor mechanism disruption (BEMD) leads to worse outcomes than unilateral injuries. Patients with BEMD experienced more comorbidities, higher complication rates, and poorer functional recovery.
Area of Science:
- Orthopaedic Surgery
- Trauma Care
- Reconstructive Surgery
Background:
- Simultaneous bilateral extensor mechanism disruption (BEMD) is a rare injury with poorly defined outcomes.
- Understanding comorbidities and complications is crucial for managing BEMD.
Purpose of the Study:
- To compare clinical outcomes, comorbidities, and complications between patients with BEMD and unilateral extensor mechanism disruption (UEMD).
- To establish a clearer understanding of the BEMD patient profile and associated risks.
Main Methods:
- Retrospective review of adult patients with quadriceps or patellar tendon ruptures (2012-2017).
- Comparison of BEMD (n=14) versus UEMD (n=221) using statistical analysis (Student's t-tests, Fisher's exact tests).
Main Results:
- BEMD patients had higher BMI, ASA scores, and worse PROMIS physical function scores.
- BEMD group experienced longer hospital stays (4x) and higher repair failure rates (3x) compared to UEMD.
- Despite worse initial outcomes, all BEMD patients achieved ambulation, and most returned to work.
Conclusions:
- Simultaneous BEMD is rare (6% of series) but associated with significantly more comorbidities and poorer outcomes than UEMD.
- Orthopaedic surgeons must maintain high awareness of increased risks and complications in BEMD patients.
- While challenging, BEMD patients can achieve functional recovery and return to work.
Related Concept Videos
Fixing Double-strand Breaks
14.4K
The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
14.4K
Fixing Double-strand Breaks
4.3K
4.3K
Double Resonance Techniques: Overview
734
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
Spin decoupling is usually achieved by...
734
Reaction Mechanisms
30.6K
Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
30.6K
Mechanical Protein Functions
5.5K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force.
5.5K
Mechanism of Conjugation
946
Bacterial conjugation is a mechanism of horizontal gene transfer that enables the exchange of genetic material between bacterial cells through direct contact. This process is facilitated by a donor cell carrying a conjugative plasmid, which encodes genes necessary for pilus formation, DNA replication, and transfer. The conjugative plasmid plays a central role in initiating and executing the transfer of genetic material.The tra region of the conjugative plasmid encodes proteins responsible for...
946

