Related Experiment Video

Updated: Jan 25, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K

Fracture risk in chronic kidney disease: A Korean population-based cohort study

Young Eun Kwon1, Hyung Yun Choi2, Sol Kim1

  • 1Department of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.

Kidney Research and Clinical Practice
|May 9, 2019
PubMed

Insights

Patients with end-stage renal disease (ESRD) on dialysis face higher fracture risks than pre-dialysis chronic kidney disease (CKD) patients. Phosphate binders are associated with a reduced fracture risk in ESRD patients, highlighting their importance in managing bone health.

Area of Science:

  • Nephrology
  • Orthopedics
  • Pharmacology

Background:

  • Chronic kidney disease (CKD)-mineral and bone disorder (MBD) is linked to declining kidney function and increased fracture risk.
  • Phosphate binder use is a cornerstone in managing hyperphosphatemia within CKD-MBD.
  • Understanding fracture risk differences between pre-dialysis and dialysis patients is crucial for patient care.

Purpose of the Study:

  • To compare fracture risk in pre-dialysis CKD patients versus end-stage renal disease (ESRD) patients on dialysis.
  • To investigate the impact of phosphate binders on fracture risk specifically in ESRD patients.

Main Methods:

  • Retrieved data from 89,533 CKD patients (2012-2016) from the Health Insurance Review and Assessment Service Database.
  • Analyzed CKD diagnosis, dialysis status, fracture history, and phosphate binder prescription history.
  • Employed multivariate Cox regression analyses to assess associations between dialysis, phosphate binders, and fracture risk.

Main Results:

  • Fracture rates were 74 per 1,000 patient-years in pre-dialysis CKD and 84 per 1,000 patient-years in dialysis patients.
  • ESRD patients on dialysis exhibited a significantly higher fracture risk (HR, 1.16; P < 0.001) compared to pre-dialysis CKD patients.
  • Patients not taking phosphate binders had a 20.0% higher fracture risk than those on phosphate binders.

Conclusions:

  • Fractures are more common in ESRD patients undergoing dialysis than in pre-dialysis CKD patients.
  • Phosphate binder therapy is linked to a decreased risk of fractures in ESRD patients.
  • These findings underscore the importance of managing mineral and bone disorders in CKD patients to mitigate fracture risk.
Abstract

Keywords:
Chronic renal insufficiencyDialysisFracturePhosphate binder

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.6K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.4K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
613
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
601
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
377
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
342
Conservation of Small Populations02:04

Conservation of Small Populations

Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
16.7K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.1K