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Updated: Jan 25, 2026

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma
Published on: September 3, 2021
Macrophages in Colorectal Cancer Liver Metastases
Nina Cortese1, Cristiana Soldani2, Barbara Franceschini3
1Department of Immunology and Inflammation, Humanitas Clinical and Research Center, 20089 Rozzano, Italy. nina.cortese@humanitasresearch.it.
Abstract:
Tumor-associated macrophages (TAMs) provide a nurturing microenvironment for metastasis and are concomitantly key determinants of the efficacy of anticancer strategies. TAM represent an extremely heterogeneous population in terms of cell morphology, functions, and tissue localization. Colorectal liver metastases (CLM) display a high heterogeneity, responsible for a wide array of clinical presentations and responsiveness to treatments. In the era of precision medicine, there is a critical need of reliable prognostic markers to improve patient stratification, and, for their predominance in metastatic tissues, TAMs are emerging as promising candidates.
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