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Updated: Jan 25, 2026
04:41
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
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Circulating microparticles in cardiovascular disease: going on stage!
Mauricio Fernández1, Sebastián D Calligaris1
1a Departamento de Cardiología , Universidad del Desarrollo Clínica Alemana , Santiago , Chile.
Summary
Circulating microparticles show promise as novel biomarkers for cardiovascular diseases (CVDs). These indicators of vascular damage can supplement existing risk calculators, improving cardiovascular risk evaluation.
Area of Science:
- Biomarkers and diagnostics
- Cardiovascular research
- Vascular biology
Background:
- Cardiovascular diseases (CVDs) are a leading global cause of mortality.
- Current risk calculators for CVDs have inherent uncertainties.
- Newer diagnostic methods focus on indicators of vascular or cardiac damage.
Purpose of the Study:
- To review the discoveries supporting circulating microparticles as biomarkers for cardiovascular risk.
- To highlight the potential of microparticles as a complementary tool in CVD risk assessment.
Main Methods:
- Systematic literature search on Medline.
- Keywords included: cardiovascular diseases, microparticles, miRNAs, diagnosis, prognosis, biomarkers, microvesicles.
- Analysis of articles related to microparticles as CVD biomarkers and clinical studies on their preventive potential.
Main Results:
- Identified nine articles supporting the concept of microparticles as CVD biomarkers.
- Found 15 and 12 studies on the potential of microparticles in primary and secondary CVD prevention, respectively.
- Circulating microparticle levels correlate with cardiovascular damage.
Conclusions:
- Circulating microparticles are associated with cardiovascular damage in both asymptomatic and post-event patients.
- These microparticles are emerging as valuable diagnostic and predictive biomarkers for CVDs.
- Microparticles offer a promising complementary approach to current CVD risk evaluation strategies.
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