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Multiple HLA-matched platelet transfusions for a single patient with broad anti-HLA antibodies: a case report

Takeshi Hagino1, Nelson Hirokazu Tsuno2, Fumihiro Azuma2

  • 1a Department of Hematology , Tama-Hokubu Medical Center, Tokyo Metropolitan Health and Medical Treatment Corporation , Tokyo , Japan.

Platelets
|May 10, 2019
PubMed

The efficacy of 30 platelet concentrate (PC) products transfused to a patient with myelodysplastic syndrome (MDS) was evaluated by calculating the 1-hour post-transfusion corrected count increment (1h-CCI). Of the 30 transfusions, all HLA-A/B-matched, the cross-match (CM) test was negative in 23 (CM(-)-PC) and weakly positive (CM(+)-PC) in 2, and the CM test was not conducted in 5 (non-CM-PC). The effective rate was higher with CM(-)-PC compared to non-CM-PC (82.6% vs 60%), but statistical significance was not achieved, which suggested that the CM test of PC may still be a not satisfactorily effective predictor of PC refractoriness. Studies are ongoing in Japan to confirm on the importance of CM test of PC.

Keywords:
ABH-compatible platelet unitsAnti-HLA antibodycorrected count incrementcrossmatch-positive platelet unitsplatelet transfusion refractoriness

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