Mechanical measurement of the human cerebellum under compressive loading

The cerebellum is responsible for controlling the posture and walking stability of the body. The cerebellum can subject to the traumatic injuries following by complicated clinical problems, i.e., the cerebellar pathologies. Application of the computational models can be helpful to figure out the injury mechanisms of the cerebellum, however, there is a lack of knowledge on the mechanical properties of the cerebellum under compressive loading. Therefore, this study aimed to perform an experimental study to measure the mechanical properties of 17 male individuals' cerebellum under the series of compressive loadings. The resulted stress-strain data of the cerebellum revealed the elastic modulus and maximum/failure stress of 13.48 ± 2.65 (Mean ± SD) and 19.65 ± 3.89 kPa, respectively. The findings of this study have implications not only for understanding the mechanical properties of the human cerebellum tissue under the compressive loading, but also for providing a raw data for the doctors and biomechanical experts as the mechanical threshold of the cerebellum as well as computational modelling of the traumatic brain injuries.