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Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
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Induced Electric Dipoles01:28

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A permanent electric dipole orients itself along an external electric field. This rotation can be quantified by defining the potential energy because the external torque does work in rotating it. Then, the potential energy is minimum at the parallel configuration and maximum at the antiparallel configuration. While the former is a stable equilibrium, the latter is an unstable equilibrium.
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The fact that emfs are induced in circuits implies that work is being done on the conduction electrons in the wires. What can possibly be the source of this work? We know that it’s neither a battery nor a magnetic field, as a battery does not have to be present in a circuit where current is induced, and magnetic fields never do any work on moving charges. The source of the work is in fact an electric field that is induced in the wires. For example, if a stationary conductor is placed in a...
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Updated: Jan 25, 2026

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
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Apatinib-induced hyperammonemic encephalopathy.

Yan Liu1, Xiao Chen1, Xiang Gao1

  • 1Department of Pharmacy, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
|May 10, 2019
PubMed
Summary

Apatinib, a cancer drug, may cause hyperammonemic encephalopathy, a brain condition. This risk exists even at low doses, requiring clinical awareness for patients on vascular endothelial growth factor receptor-tyrosine kinase inhibitors.

Area of Science:

  • Oncology
  • Neurology
  • Pharmacology

Background:

  • Apatinib is a small-molecule inhibitor targeting vascular endothelial growth factor receptor-2.
Keywords:
Adverse drug reactionapatinibhepatic carcinomahyperammonemic encephalopathy

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  • It shows anticancer activity in various malignancies like hepatocellular carcinoma.
  • Hyperammonemic encephalopathy is a serious neurological condition.