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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
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Metachronous extraskeletal (soft tissue) epithelioid osteogenic sarcoma: a case report
Gireesha Rawal1, Charanjeet Ahluwalia2, Amit Kumar Yadav1
1Department of Pathology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, 110029, India.
Journal of Medical Case Reports
|May 10, 2019
Summary
This case report details a rare instance of extraskeletal epithelioid osteosarcoma in the hand, occurring 3 years after primary osteosarcoma of the leg. Early detection and aggressive treatment are crucial for improving survival in metachronous osteosarcoma.
Area of Science:
- Oncology
- Orthopedic Oncology
- Pathology
Background:
- Metachronous osteosarcoma, a rare condition, presents diagnostic challenges regarding its origin (primary vs. metastatic).
- Extraskeletal osteosarcoma, particularly in soft tissues, is exceptionally uncommon.
Observation:
- A 49-year-old man presented with a left-hand soft tissue mass, initially suspected as an abscess or hematoma.
- Imaging revealed a soft tissue lesion without obvious bone involvement.
- Biopsy confirmed epithelioid osteosarcoma, with a history of primary osteosarcoma in the right leg 3 years prior.
Findings:
- The patient was diagnosed with extraskeletal epithelioid osteogenic sarcoma of the left hand as a metachronous tumor.
- This represents a potentially first-in-literature case of soft tissue epithelioid osteosarcoma occurring years after a primary limb osteosarcoma.
Implications:
- Metachronous osteosarcoma, especially extraskeletal, has a poor prognosis, often worse than lung-limited relapse.
- Combined-modality therapy (surgery, chemotherapy) may improve long-term survival for late-stage metachronous osteosarcoma.
- Lifelong surveillance is essential for osteosarcoma survivors to detect metachronous disease, which should be treated with curative intent.
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