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[OAS1 gene polymorphism is associated with central nervous system involvement in children with enterovirus 71
L I Yaping1, Zhai Song1, Wang Wenjun1
1Department of Infectious Diseases, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Insights
The OAS1 gene rs2660 polymorphism is linked to central nervous system (CNS) involvement in enterovirus 71 (EV71) infections. Children with the OAS1 rs2660 AG genotype show a higher likelihood of developing CNS complications after EV71 infection.
Area of Science:
- Virology
- Genetics
- Immunology
Background:
- Enterovirus 71 (EV71) is a significant pathogen causing hand, foot, and mouth disease, with potential for severe neurological complications.
- The 2'-5' oligoadenylate synthetase 1 (OAS1) gene plays a crucial role in the innate immune response against viral infections.
- Genetic variations in OAS1 may influence individual susceptibility to viral infections and their clinical outcomes.
Purpose of the Study:
- To investigate the association between OAS1 gene single nucleotide polymorphisms (SNPs) and the risk of central nervous system (CNS) involvement in children with EV71 infection.
- To determine if specific OAS1 SNPs (rs2660 and rs1131454) are associated with susceptibility to EV71 infection or its neurological complications.
Main Methods:
- A case-control study involving 180 children with EV71 infection (72 mild, 108 severe with CNS involvement) and 201 healthy controls.
- Genotyping of OAS1 SNPs rs2660 and rs1131454 was performed using the SNPscan method.
- Statistical analysis compared genotype and allele frequencies between groups.
Main Results:
- No significant association was found between OAS1 rs2660 or rs1131454 SNPs and overall susceptibility to EV71 infection.
- OAS1 rs2660 polymorphism showed a significant difference between children with CNS involvement and those with mild EV71 infection.
- Children with CNS involvement had a higher frequency of the OAS1 rs2660 AG genotype and a lower frequency of the GG genotype compared to mild cases.
Conclusions:
- OAS1 rs2660 and rs1131454 SNPs are not associated with susceptibility to EV71 infection.
- OAS1 rs2660 SNPs are significantly correlated with the susceptibility to CNS involvement in EV71 infection.
- The OAS1 rs2660 AG genotype is a potential risk factor for developing CNS complications following EV71 infection.
Objective:
We investigated the association between OAS1 gene polymorphism and susceptibility to central nervous system (CNS) involvement of enterovirus (EV)71 infection.
Methods:
This case-control study was conducted among 180 children with EV71 infection, including 72 with mild infections without any complications and 108 with severe infections and CNS involvement; 201 children undergoing routine physical examination served as the healthy controls. For all the participants, the single nucleotide polymorphisms (SNPs) at OAS1 rs2660 and rs1131454 were analyzed using SNPscan multiple SNP typing methods.
Results:
No significant differences were found between the case and control groups in genotype or allele distributions of rs2660 and rs1131454. OAS1 rs2660 polymorphism was significantly different between the children with CNS involvement and those with mild EV71 infection, and the genotype AG frequency was higher and the genotype GG frequency was lower in children with CNS involvement. No significant difference was found in the distribution of genotypes or alleles of rs1131454 between the children with CNS involvement and those with mild EV71 infection.
Conclusions:
OAS1 gene rs2660 and rs1131454 SNPs are not associated with the susceptibility to or CNS involvement of EV71 infection, but OAS1 rs2660 SNPs are significantly correlated with the susceptibility to CNS involvement in EV71 infection. Children carrying OAS1 rs2660 AG genotype are more likely to have CNS involvement after EV71 infection.
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