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Updated: Jan 25, 2026
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
[Association between drinking and all-cause mortality in patients with ischemic stroke]
Qianwen Zheng1, Yawen Li1, Lu Zhang1
1Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Insights
Alcohol consumption patterns influence mortality risk in ischemic stroke patients. Moderate drinking frequency and duration before stroke, along with continued drinking post-stroke, were linked to lower death rates.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Public Health
Background:
- Ischemic stroke is a leading cause of death and disability worldwide.
- Understanding lifestyle factors, such as alcohol consumption, is crucial for managing post-stroke outcomes.
- Previous research on alcohol and stroke mortality has yielded mixed results.
Purpose of the Study:
- To investigate the association between alcohol drinking patterns and all-cause mortality in patients who have experienced an ischemic stroke.
- To identify specific drinking behaviors that may influence survival rates after ischemic stroke.
Main Methods:
- A cohort of 855 patients with first-episode ischemic stroke was followed for up to 9 years.
- Cox regression models were used to analyze the impact of pre-stroke drinking status, drinking duration, frequency, and post-stroke drinking behavior on mortality.
- Baseline characteristics were compared between drinkers and non-drinkers using the Chi-square test.
Main Results:
- Drinking during the follow-up period was significantly associated with a reduced risk of death (P=0.001).
- Drinking for less than 28 years prior to stroke (P=0.035) and moderate drinking frequency (5-20 times/month for males, 4-9 times/month for females; P=0.030) were linked to lower mortality.
- No significant association was found between pre-stroke drinking status or average single alcohol intake and post-stroke death.
Conclusions:
- Drinking duration and frequency before stroke, as well as drinking status during follow-up, are associated with all-cause mortality in ischemic stroke patients.
- Further research into specific drinking behaviors during the follow-up period is warranted to elucidate the complex relationship between alcohol and post-stroke survival.
Objective:
To investigate the association between alcohol drinking and all-cause death in patients with ischemic stroke.
Methods:
Between January, 2010 and July, 2018, consecutive patients with first-episode ischemic stroke admitted in the West China Hospital, Sichuan University were enrolled, and all the patients were followed up every 3 months.Chi-square test was used to compare the differences in the baseline characteristics between the pre-stroke drinkers and the nondrinkers.The Cox regression model was used to analyze the effects of drinking status, drinking years, drinking frequency, average single alcohol intake before stroke and drinking status during the follow-up period on the mortality of patients after discharge.
Results:
A total of 855 patients with ischemic stroke were enrolled, and deaths occurred in 140 of these patients.Chi-square test showed significant differences in gender (P < 0.001), weekly physical exercise time (P=0.035), smoking (P < 0.001), and heart disease (P < 0.001) between the pre-stroke drinkers and nondrinkers.Multivariate Cox regression analysis showed that drinking during the follow-up period (P=0.001), drinking for less than 28 years before stroke (P=0.035) and a moderate drinking frequency (5 to 20 times per month for males and 4 to 9 times per month for females; P=0.030) were associated with a lowered risk of death after discharge.No significant effects of pre-stroke drinking status or average single alcohol intake were found on death after ischemic stroke.
Conclusions:
The drinking years and drinking frequency before stroke and drinking status during the follow-up period are related to the all-cause mortality in patients with ischemic stroke.Investigations of the more specific variables of drinking behaviors during the follow-up period are needed to further clarify the association between drinking and death after ischemic stroke.
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