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Major Stressful Life Events and Risk of Developing Lung Cancer: A Case-Control Study
Syed H Jafri1, Faisal Ali1, Arash Mollaeian1
1Division of Oncology, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Clinical Medicine Insights. Oncology
|May 10, 2019
Summary
Major stressful life events within five years increased lung cancer risk. Beta-blocker use may offer protection against lung cancer development.
Area of Science:
- Oncology
- Psychosocial Oncology
- Epidemiology
Background:
- Lung cancer is a leading cause of cancer mortality, strongly associated with smoking.
- The potential role of major stressful life events as a risk factor for lung cancer requires investigation.
Purpose of the Study:
- To determine if major stressful life events are a risk factor for developing lung cancer.
- To explore the association between stressful life events and lung cancer incidence.
Main Methods:
- A matched case-control study was conducted.
- Data on major stressful life events were collected using the modified Holmes-Rahe stress scale.
- 301 patients (102 lung cancer cases, 199 controls) were enrolled and matched for age, sex, and smoking status.
Main Results:
- No difference was found in the lifetime rate of stressful life events between lung cancer cases and controls.
- Lung cancer cases were significantly more likely to have experienced a major stressful life event within the preceding five years (OR=1.78, P=0.03).
- Beta-blocker use was significantly higher in controls, suggesting a potential protective effect (OR=0.42, P=0.0007).
Conclusions:
- Experiencing major stressful life events in the five years prior to diagnosis is associated with an increased likelihood of lung cancer.
- Beta-blocker medication may have a protective effect against lung cancer.
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